Published in:
01-05-2010 | Poster presentation
Microarray based expression profiling of BRCA1 mutated human tumours using a breast-specific platform to identify a profile of BRCA1 deficiency
Authors:
E Lamers, FA McDyer, JM Mulligan, F Couch, KI Savage, NE O'Brien, PB Mullan, RD Kennedy, DP Harkin, JE Quinn
Published in:
Breast Cancer Research
|
Special Issue 1/2010
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Excerpt
The BRCA1 tumour suppressor gene is mutated in a significant proportion of hereditary breast cancer cases. Downregulation of BRCA1 mRNA and protein expression has also been reported in approximately 30% of sporadic breast cancer cases. BRCA1 is strongly implicated in the maintenance of genomic stability by its involvement in multiple cellular pathways including DNA damage signalling, DNA repair, cell cycle regulation, protein ubiquitination, chromatin remodelling, transcriptional regulation and apoptosis. Both pathological and gene expression profiling studies provide evidence that breast cancers with germline mutations in BRCA1 are different from non-BRCA1-related breast cancers. …
