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Breast Cancer Research
Published in: Breast Cancer Research 3/2009

01-12-2009 | Short communication

Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy?

Author: Ian E Smith

Published in: Breast Cancer Research | Special Issue 3/2009

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Excerpt

The BIG1-98 trial, involving over 8,000 postmenopausal women with hormone receptor-positive early breast cancer, was a four-arm trial of adjuvant endocrine therapy for early breast cancer comparing 5 years of tamoxifen treatment versus 5 years of letrozole treatment versus 2 years of tamoxifen then switch to letrozole treatment versus 2 years of letrozole then switch to tamoxifen treatment. The initial results of the trial, which compared only the upfront tamoxifen and letrozole arms, showed a small but highly statistically significant disease-free survival (DFS) advantage in favour of letrozole with a hazard ratio of 0.81 and an absolute 4-year improvement in DFS of 2.7% [1]. …
Literature
1.
TBreast International Group (BIG) 1-98 Collaborative Group, Thürlimann B, Keshaviah A, Coates AS, Mouridsen H, Mauriac L, Forbes JF, Paridaens R, Castiglione-Gertsch M, Gelber RD, Rabaglio M, Smith I, Wardley A, Price KN, Goldhirsch A: A comparison of letrozole and tamoxifen in postmenopausal women with early breast cancer. N Engl J Med. 2005, 353: 2747-2757. 10.1056/NEJMoa052258.CrossRef
2.
Duffy S, Jackson TL, Lansdown M, Philips K, Wells M, Pollard S, Clack G, Coibion M, Bianco AR: The ATAC ('Arimidex', Tamoxifen, Alone or in Combination) adjuvant breast cancer trial: first results of the endometrial sub-protocol following 2 years of treatment. Hum Reprod. 2006, 21: 545-553. 10.1093/humrep/dei322.CrossRefPubMed
3.
BIG 1-98 Collaborative Group, Mouridsen H, Giobbie-Hurder A, Goldhirsch A, Thürlimann B, Paridaens R, Smith I, Mauriac L, Forbes JF, Price KN, Regan MM, Gelber RD, Coates AS: Letrozole therapy alone or in sequence with tamoxifen in women with breast cancer. N Engl J Med. 2009, 361: 766-776. 10.1056/NEJMoa0810818.CrossRef
4.
BIG 1-98 Collaborative Group, Mouridsen H, Giobbie-Hurder A, Goldhirsch A, Thürlimann B, Paridaens R, Smith I, Mauriac L, Forbes JF, Price KN, Regan MM, Gelber RD, Coates AS: Endocrine therapy plus zoledronic acid in premenopausal breast cancer. N Engl J Med. 2009, 360: 679-691. 10.1056/NEJMoa0806285.CrossRef
Metadata
Title
Do BIG1-98 and ZOFAST demand a change in guidelines for endocrine therapy?
Author
Ian E Smith
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 3/2009
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2437

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