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Breast Cancer Research
Published in: Breast Cancer Research 6/2009

01-12-2009 | Review

Epithelial to mesenchymal transition and breast cancer

Authors: Eva Tomaskovic-Crook, Erik W Thompson, Jean Paul Thiery

Published in: Breast Cancer Research | Issue 6/2009

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Abstract

Epithelial-mesenchymal plasticity in breast carcinoma encompasses the phenotypic spectrum whereby epithelial carcinoma cells within a primary tumor acquire mesenchymal features and re-epithelialize to form a cohesive secondary mass at a metastatic site. Such plasticity has implications in progression of breast carcinoma to metastasis, and will likely influence response to therapy. The transcriptional and epigenetic regulation of molecular and cellular processes that underlie breast cancer and result in characteristic changes in cell behavior can be monitored using an increasing array of marker proteins. Amongst these markers exists the potential for emergent prognostic, predictive and therapeutic targeting.
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Metadata
Title
Epithelial to mesenchymal transition and breast cancer
Authors
Eva Tomaskovic-Crook
Erik W Thompson
Jean Paul Thiery
Publication date
01-12-2009
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2009
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr2416

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