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Journal of Mammary Gland Biology and Neoplasia

Published in:

01-03-2009

The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies

Authors: Brett G. Hollier, Kurt Evans, Sendurai A. Mani

Published in: Journal of Mammary Gland Biology and Neoplasia | Issue 1/2009

Abstract

During cancer progression, some cells within the primary tumor may reactivate a latent embryonic program known as epithelial-to-mesenchymal transition (EMT). Through EMT, transformed epithelial cells can acquire the mesenchymal traits that seem to facilitate metastasis. Indeed, there is accumulating evidence that EMT and mesenchymal-related gene expression are associated with aggressive breast cancer subtypes and poor clinical outcome in breast cancer patients. More recently, the EMT program was shown to endow normal and transformed mammary epithelial cells with stem cell properties, including the ability to self-renew and efficiently initiate tumors. This link between EMT and stem cells may have numerous implications in the progression of breast tumors. The EMT process may facilitate the generation of cancer cells with the mesenchymal traits needed for dissemination as well as the self-renewal properties needed for initiation of secondary tumors. Breast cancer stem cells are resistant to many conventional cancer therapies, which can promote tumor relapse. Therefore, the generation of cancer stem cells by EMT may promote the development of refractory and resistant breast tumors. The purpose of this review is to summarize the findings related to EMT and stem cells in cancer progression and therapy resistance.

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Title: The Epithelial-to-Mesenchymal Transition and Cancer Stem Cells: A Coalition Against Cancer Therapies
Authors: Brett G. Hollier
Kurt Evans
Sendurai A. Mani
Publication date: 01-03-2009
Publisher: Springer US
Published in: Journal of Mammary Gland Biology and Neoplasia / Issue 1/2009
Print ISSN: 1083-3021
Electronic ISSN: 1573-7039
DOI: https://doi.org/10.1007/s10911-009-9110-3

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Other articles of this Issue 1/2009

Cellular Quiescence in Mammary Stem Cells and Breast Tumor Stem Cells: Got Testable Hypotheses?

Radiation Resistance of Breast Cancer Stem Cells: Understanding the Clinical Framework

ABC Transporters, Drug Resistance, and Cancer Stem Cells

Tumor-Initiating Cells and Treatment Resistance: How Goes the War?

Resistance to Endocrine Therapy: Are Breast Cancer Stem Cells the Culprits?

Treatment Resistance in Stem Cells and Breast Cancer

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