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Breast Cancer Research
Published in: Breast Cancer Research 2/2008

01-05-2008 | Poster presentation

Cellular localization of the proto-oncogenic p53 inhibitor AGR2 protein in breast cancer

Authors: A Fourtouna, T Hupp

Published in: Breast Cancer Research | Special Issue 2/2008

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Excerpt

Proteomic technologies verified AGR-2 as a protein family overexpressed in human cancers, including breast, prostate and oesophagus cancers, with the ability to inhibit the tumour suppressor protein p53 [1]. The AGR-2 gene is a hormone responsive gene with an unexpected induction by the anticancer drug tamoxifen highlighting the proto-oncogenic role of this protein. The hAGR-2 gene was first described in the MCF-7 breast carcinoma cell line, and was found to be coexpressed with the estrogen receptor (ER), in ER-positive cell lines [2, 3]. Moreover, it was recently revealed that AGR-2 is secreted from androgen-inducible cell lines in prostate cancer cell lines [4]. …
Literature
1.
Pohler E, Craig AL, Cotton J, Lawrie L, Dillon J, Ross P, Kernohan N, Hupp T: The Barrett's antigen anterior gradient-2 silences the p53 transcriptional response to DNA damage. Mol Cell Proteomics. 2004, 3: 534-547. 10.1074/mcp.M300089-MCP200.CrossRefPubMed
2.
Thompson DA, Weigel RJ: hAG-2, the human homologue of the Xenopus laevis cement gland gene XAG-2, is coexpressed with estrogen receptor in breast cancer cell lines. Biochem Biophys Res Commun. 1998, 251: 111-116. 10.1006/bbrc.1998.9440.CrossRefPubMed
3.
Kuang WW, Thompson DA, Hoch RV, Weigel RJ: Differential screening and suppression subtractive hybridization identified genes differentially expressed in an estrogen receptor-positive breast carcinoma cell line. Nucleic Acids Res. 1998, 26: 1116-1123. 10.1093/nar/26.4.1116.CrossRefPubMedPubMedCentral
4.
Zhang J, Gong A, Cheville J, Smith D, Young C: AGR-2, an androgen-inducible secretory protein overexpressed in prostate cancer. Genes Chromosomes Cancer. 2005, 43: 249-259. 10.1002/gcc.20188.CrossRefPubMed
Metadata
Title
Cellular localization of the proto-oncogenic p53 inhibitor AGR2 protein in breast cancer
Authors
A Fourtouna
T Hupp
Publication date
01-05-2008
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2008
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1898

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