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Breast Cancer Research
Published in: Breast Cancer Research 6/2007

01-12-2007 | Review

Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer

Authors: Teresa L Mastracci, Fouad I Boulos, Irene L Andrulis, Wan L Lam

Published in: Breast Cancer Research | Issue 6/2007

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Abstract

Advances in genomic technology have improved our understanding of the genetic events that parallel breast cancer development. Because almost all mammary carcinomas develop in the terminal duct lobular units of the breast, understanding the events involved in mammary gland development make it possible to recognize those events that, when altered, contribute to breast neoplasia. In this review we focus on lobular carcinomas, discussing the pathology, development, and progression of premalignant lobular lesions from a genomic point of view. We highlight studies utilizing genomic approaches and describe how these investigations have furthered our understanding of the complexity of premalignant breast lesions.
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Metadata
Title
Genomics and premalignant breast lesions: clues to the development and progression of lobular breast cancer
Authors
Teresa L Mastracci
Fouad I Boulos
Irene L Andrulis
Wan L Lam
Publication date
01-12-2007
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2007
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1785

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