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01-10-2007 | Commentary

Clinical trial update: implications and management of residual disease after neoadjuvant therapy for breast cancer

Authors: Erica L Mayer, Lisa A Carey, Harold J Burstein

Published in: Breast Cancer Research | Issue 5/2007

Abstract

Neoadjuvant chemotherapy for breast cancer has a well-established role in the management of patients with locally advanced or early stage disease. Multiple trials have demonstrated superior survival outcomes in individuals achieving a pathologic complete response at the time of definitive surgery, and sophisticated genetic methods may predict which patients will be in this category. Those with less than a pathologic complete response remain at significant risk of recurrent disease, and currently no further standard therapy exists. Ongoing studies of novel agents may lead to improved therapeutic outcomes for this high-risk population.

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Title: Clinical trial update: implications and management of residual disease after neoadjuvant therapy for breast cancer
Authors: Erica L Mayer
Lisa A Carey
Harold J Burstein
Publication date: 01-10-2007
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue 5/2007
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1755

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