Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress 2023 EHA Congress 2023 ASCO Annual Meeting
Clinical Collections
Advances in Alzheimer’s

Keynote webinar | Spotlight on sleep in brain health

LIVE: Thursday 2nd May 2024, 18:00-19:30 (CEST)

Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
ADVANCED SEARCH
Log in
Top
Breast Cancer Research
Published in: Breast Cancer Research 6/2006

01-12-2006 | Commentary

Intrauterine exposures, pregnancy estrogens and breast cancer risk: where do we currently stand?

Author: Pagona Lagiou

Published in: Breast Cancer Research | Issue 6/2006

Login to get access

Abstract

Since 1990, when a hypothesis on intrauterine influences on breast cancer risk was published, several studies have provided supportive, indirect evidence by documenting associations of birth weight and other correlates of the prenatal environment with breast cancer risk in offspring. Recent results from a unique cohort of women with documented exposure to diethylstilbestrol in utero have provided direct evidence in support of a potential role of pregnancy oestrogens on breast cancer risk in offspring.
Literature
1.
Rothman KJ, MacMahon B, Lin TM, Lowe CR, Mirra AP, Ravnihar B, Salber EJ, Trichopoulos D, Yuasa S: Maternal age and birth rank of women with breast cancer. J Natl Cancer Inst. 1980, 65: 719-722.PubMed
2.
3.
Trichopoulos D: Hypothesis: does breast cancer originate in utero?. Lancet. 1990, 335: 939-940. 10.1016/0140-6736(90)91000-Z.CrossRefPubMed
4.
Trichopoulos D, Lipman R: Mammary gland mass and breast cancer risk. Epidemiology. 1992, 3: 523-526.CrossRefPubMed
5.
Adami H-O, Signorello LB, Trichopoulos D: Towards an understanding of breast cancer etiology. Semin Cancer Biol. 1998, 8: 255-262. 10.1006/scbi.1998.0077.CrossRefPubMed
6.
Trichopoulos D, Lagiou P, Adami HO: Towards an integrated model for breast cancer etiology: the crucial role of the number of mammary tissue-specific stem cells. Breast Cancer Res. 2005, 7: 13-17. 10.1186/bcr966.CrossRefPubMed
7.
Michels KB, Trichopoulos D, Robins JM, Rosner BA, Manson JE, Hunter DJ, Colditz GA, Hankinson SE, Speizer FE, Willett WC: Birth weight as a risk factor for breast cancer. Lancet. 1996, 348: 1542-1546. 10.1016/S0140-6736(96)03102-9.CrossRefPubMed
8.
Vatten LJ, Maehle BO, Lund Nilsen TI, Tretli S, Hsieh C-c, Trichopoulos D, Stuver SO: Birth weight as a predictor of breast cancer: a case-control study in Norway. Br J Cancer. 2002, 86: 89-91. 10.1038/sj.bjc.6600011.CrossRefPubMedPubMedCentral
9.
Ahlgren M, Sorensen T, Wohlfahrt J, Haflidadottir A, Holst C, Melbye M: Birth weight and risk of breast cancer in a cohort of 106,504 women. Int J Cancer. 2003, 107: 997-1000. 10.1002/ijc.11481.CrossRefPubMed
10.
Cerhan JR, Kushi LH, Olson JE, Rich SS, Zheng W, Folsom AR, Sellers TA: Twinship and risk of postmenopausal breast cancer. J Natl Cancer Inst. 2000, 92: 261-265. 10.1093/jnci/92.3.261.CrossRefPubMed
11.
Ekbom A, Hsieh CC, Lipworth L, Adami HO, Trichopoulos D: Intrauterine environment and breast cancer risk in women: a population-based study. J Natl Cancer Inst. 1997, 89: 71-76. 10.1093/jnci/89.1.71.CrossRefPubMed
12.
Hsieh C-c, Tzonou A, Trichopoulos D: Birth order and breast cancer risk. Cancer Causes Control. 1991, 2: 95-98. 10.1007/BF00053127.CrossRefPubMed
13.
Hatch EE, Palmer JR, Titus-Ernstoff L, Noller KL, Kaufman RH, Mittendorf R, Robboy SJ, Hyer M, Cowan CM, Adam E, et al: Cancer risk in women exposed to diethylstilbestrol in utero. JAMA. 1998, 280: 630-634. 10.1001/jama.280.7.630.CrossRefPubMed
14.
Palmer JR, Hatch EE, Rosenberg CL, Hartge P, Kaufman RH, Titus-Ernstoff L, Noller KL, Herbst AL, Rao RS, Troisi R, et al: Risk of breast cancer in women exposed to diethylstilbestrol in utero: prelimiinary results (United States). Cancer Causes Control. 2002, 13: 753-758. 10.1023/A:1020254711222.CrossRefPubMed
15.
Palmer JR, Wise LA, Hatch EE, Troisi R, Titus-Ernstoff L, Strohsnitter W, Kaufman R, Herbst AL, Noller KL, Hyer M, et al: Prenatal diethylstilbestrol exposure and risk of breast cancer. Cancer Epidemiol Biomarkers Prev. 2006, 15: 1509-1514. 10.1158/1055-9965.EPI-06-0109.CrossRefPubMed
16.
Herbst AL, Ulfelder H, Poskanzer DC: Adenocarcinoma of the vagina. Association of maternal stilbestrol therapy with tumor appearance in young women. N Engl J Med. 1971, 284: 878-881.CrossRefPubMed
17.
Loman N, Johannsson O, Kristoffersson U, Olsson H, Borg A: Family history of breast and ovarian cancers and BRCA1 and BRCA2 mutations in a population-based series of early-onset breast cancer. J Natl Cancer Inst. 2001, 93: 1215-1223. 10.1093/jnci/93.16.1215.CrossRefPubMed
18.
Baik I, Becker PS, DeVito WJ, Lagiou P, Ballen K, Quesenberry PJ, Hsieh CC: Stem cells and prenatal origin of breast cancer. Cancer Causes Control. 2004, 15: 517-530. 10.1023/B:CACO.0000036450.06092.ce.CrossRefPubMed
19.
DeWaard F, Trichopoulos D: A unifying concept of the aetiology of breast cancer. Int J Cancer. 1988, 41: 666-669.CrossRef
20.
Baik I, Devito WJ, Ballen K, Becker PS, Okulicz W, Liu Q, Delpapa E, Lagiou P, Sturgeon S, Trichopoulos D, et al: Association of fetal hormone levels with stem cell potential: evidence for early life roots of human cancer. Cancer Res. 2005, 65: 358-363.PubMed
Metadata
Title
Intrauterine exposures, pregnancy estrogens and breast cancer risk: where do we currently stand?
Author
Pagona Lagiou
Publication date
01-12-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 6/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1615

Other articles of this Issue 6/2006

Breast Cancer Research 6/2006 Go to the issue

Research article

Genetic polymorphisms in the cyclooxygenase-2 gene, use of nonsteroidal anti-inflammatory drugs, and breast cancer risk

Research article

Molecular subtypes of breast cancer in relation to paclitaxel response and outcomes in women with metastatic disease: results from CALGB 9342

Viewpoint

A quantum leap in our knowledge of breast cancer mutations

Review

High-throughput genomic technology in research and clinical management of breast cancer. Plasma-based proteomics in early detection and therapy

Review

HER2 therapy: Molecular mechanisms of trastuzumab resistance

Research article

Estimate of overdiagnosis of breast cancer due to mammography after adjustment for lead time. A service screening study in Italy
Webinar | 19-02-2024 | 17:30 (CET)

Keynote webinar | Spotlight on antibody–drug conjugates in cancer

Watch now

Antibody–drug conjugates (ADCs) are novel agents that have shown promise across multiple tumor types. Explore the current landscape of ADCs in breast and lung cancer with our experts, and gain insights into the mechanism of action, key clinical trials data, existing challenges, and future directions.

Dr. Véronique Diéras
Prof. Fabrice Barlesi
Developed by: Springer Medicine
Image Credits