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Breast Cancer Research
Published in: Breast Cancer Research 2/2006

01-11-2006 | Poster Presentation

Functional analysis of altered Tenascin isoform expression in breast cancer

Authors: RA Alcock, JH Pringle, JA Shaw, DL Holliday, M Allen, RA Walker, JL Jones

Published in: Breast Cancer Research | Special Issue 2/2006

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Excerpt

Cellular interactions with the extracellular matrix (ECM) control many aspects of cell function. The complex ECM protein Tenascin-C (TN), which exists as multiple isoforms, is upregulated in breast cancer. We previously have identified a change in the TN isoform profile in breast cancer, with detection of two additional isoforms — TN16 and TN14/16 — not seen in normal breast [1]. The purpose of this study was to investigate directly the effects of these tumour-associated TNC isoforms on breast cancer cell behaviour. …
Literature
1.
Adams M, Jones JL, Walker RA, Pringle JH, Bell SC: Altered Tenascin-C isoform expression in invasive and pre-invasive breast cancer. Cancer Res. 2002, 62: 3289-3297.PubMed
Metadata
Title
Functional analysis of altered Tenascin isoform expression in breast cancer
Authors
RA Alcock
JH Pringle
JA Shaw
DL Holliday
M Allen
RA Walker
JL Jones
Publication date
01-11-2006
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2006
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1575

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