Published in:
01-03-2000 | Meeting abstract
Molecular analyses of human breast cancer metastasis: genetic markers of progression
Authors:
K Driouch, R Lidereau
Published in:
Breast Cancer Research
|
Special Issue 1/2000
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Excerpt
Breast tumorigenesis and metastasis result from an accumulation of genetic alterations involving 'cancer genes'. The prognostic value of these genetic alterations has been greatly investigated. However, few of them have been studied in secondary tumors, owing to the limited availability of surgical specimens. In human cancers, the genetic mechanisms underlying the metastatic process are still poorly understood. We investigated whether certain recurrent alterations could be associated with the metastatic process. We analysed the genetic profiles of primary tumors, local recurrences, and distant metastases of breast cancer. The alteration profiles in these 3 types of samples were different, suggesting distinct mechanisms of progression. …
