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01-06-2005 | Poster Presentation

Myoepithelial cell layer disruption and human breast cancer invasion

Authors: YG Man, QX Sang

Published in: Breast Cancer Research | Special Issue 2/2005

Excerpt

Human breast luminal epithelium and the stromal compartment are separated by a layer of myoepithelial (ME) cells and basement membrane, whose disruption is required for tumor invasion. Basement membrane degradation has been ascribed largely to an overproduction of proteases by the tumor and stromal cells. However, the causes and phenotypes of ME cell layer disruption and its contribution to the initiation of tumor invasion remain to be further explored. …

Man YG, Sang QX: The significance of focal myoepithelial cell layer disruptions in human breast tumor invasion: a paradigm shift from the 'protease-centered' hypothesis [review]. Exp Cell Res. 2004, 301: 103-118. 10.1016/j.yexcr.2004.08.037.CrossRefPubMed

Man YG, Shen T, Sang QX, Berg PE, Schwartz AM: Cell clusters in a subset of in situ breast tumors show an unusual growth pattern: implications for invasion and metastasis. Cancer Detect Prevent. 2005,

Title: Myoepithelial cell layer disruption and human breast cancer invasion
Authors: YG Man
QX Sang
Publication date: 01-06-2005
Publisher: BioMed Central
Published in: Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr1128

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