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Keynote webinar | Spotlight on sleep in brain health

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Quality sleep is essential for health. But what happens to our brains when sleep patterns are disturbed? Join our experts to explore the interplay between sleep disruption and neurological diseases, and the questions that you need to be asking your patients to help you prevent the harmful effects of sleep deprivation.
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Breast Cancer Research
Published in: Breast Cancer Research 2/2005

01-06-2005 | Oral Presentation

The search for low-penetrance breast cancer genes

Authors: BAJ Ponder, A Cebrian, AM Dunning, DF Easton, F Lesueur, C Luccarini, PDP Pharoah

Published in: Breast Cancer Research | Special Issue 2/2005

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Excerpt

Fifteen per cent to 20% of the familial clustering of breast cancer is explained by the effects of highly penetrant mutations in BRCA1 and BRCA2. Modelling based on the patterns of familial aggregation of breast cancer in the relatives of cases ascertained on a population basis suggests that much of the remaining familial effect is due to the combined effects of genetic variants individually of small effect. The numbers of such variants, their allele frequencies and the strength of their effects is not known. …
Metadata
Title
The search for low-penetrance breast cancer genes
Authors
BAJ Ponder
A Cebrian
AM Dunning
DF Easton
F Lesueur
C Luccarini
PDP Pharoah
Publication date
01-06-2005
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 2/2005
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr1083

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