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Published in: Breast Cancer Research 1/2000

01-03-2000 | Meeting abstract

Expression of Akt kinases related to ErbB2 and results of adjuvant therapy of breast cancer

Authors: O Stal, L Akerberg, B Nordenskjold, B Olsson, LE Rutqvist, L Skoog

Published in: Breast Cancer Research | Special Issue 1/2000

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Excerpt

It has been suggested in several studies of breast cancer that overexpression of the growth factor receptor erbB2 is associated with less benefit from certain adjuvant treatments. The mechanisms are not fully understood. The erbB2 receptor activates several signal pathways including the phosphatidyl-inositol-3-kinase (PI3-K)/Akt (also known as PKB) pathway, which is implicated in cell survival. This pathway has shown to be a target of the tumor suppressor PTEN. …
Metadata
Title
Expression of Akt kinases related to ErbB2 and results of adjuvant therapy of breast cancer
Authors
O Stal
L Akerberg
B Nordenskjold
B Olsson
LE Rutqvist
L Skoog
Publication date
01-03-2000
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue Special Issue 1/2000
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr106

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