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Breast Cancer Research
Published in: Breast Cancer Research 1/2001

01-12-2002 | Paper Report

Sequential tumour biopsies in phase I trials

Author: Fatima Cardoso

Published in: Breast Cancer Research | Issue 1/2001

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Excerpt

The development of new target-based anticancer drugs has led to the concept of "target modulation" and "optimal biological dose". It is critical to establish that the observed preclinical activity of a drug is in fact determined by the modulation of the intended target, and this should be achieved in early phase clinical trials. Another evolving notion relies on the observation that the maximum tolerated dose may not necessarily correspond to the optimal biological dose. However, a major obstacle to these new agents is the difficulty of obtaining relevant tumour tissue for laboratory analysis. …
Literature
1.
Dowlati A, Haaga J, Remick SC, Spiro TP, Gerson SL, Liu L, Berger SJ, Berger NA, Willson JKV: Sequential tumor biopsies in early phase clinical trials of anticancer agents for pharmacodynamic evaluation. Clin Cancer Res. 2001, 7: 2971-2976.PubMed
Metadata
Title
Sequential tumour biopsies in phase I trials
Author
Fatima Cardoso
Publication date
01-12-2002
Publisher
BioMed Central
Published in
Breast Cancer Research / Issue 1/2001
Electronic ISSN: 1465-542X
DOI
https://doi.org/10.1186/bcr-2002-74100

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