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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2003

01-10-2003 | Review

The role of osteoprotegerin in arthritis

Authors: Georg Schett, Kurt Redlich, Josef S Smolen

Published in: Arthritis Research & Therapy | Issue 5/2003

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Abstract

Bone erosion is a hallmark of rheumatoid arthritis. Recent evidence from experimental arthritis suggests that osteoclasts are essential for the formation of local bone erosions. Two essential regulators of osteoclastogenesis have recently been described: the receptor-activator of nuclear factor kappa B ligand, which promotes osteoclast maturation, and osteoprotegerin (OPG), which blocks osteoclastogenesis. The present review summarizes the current knowledge on the role of osteoclasts in local bone erosion. In addition, the role of OPG as a therapeutic tool to inhibit local bone erosion is addressed. Finally, evidence for OPG as an inhibitor of systemic inflammatory bone loss is discussed.
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Metadata
Title
The role of osteoprotegerin in arthritis
Authors
Georg Schett
Kurt Redlich
Josef S Smolen
Publication date
01-10-2003
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2003
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar990

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