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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2003

01-09-2003 | Meeting abstract

Regulation of inflammatory CD28- T-helper cells by HLA class I molecules: a new cellular model for Behçet's disease?

Authors: C Duftner, C Goldberger, E Märker-Hermann, M Schirmer

Published in: Arthritis Research & Therapy | Special Issue 2/2003

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Excerpt

From immunogenetical studies we learnt that Behçet's disease (BD) is associated with HLA-B*51, and to a lesser extent with HLA-B*2702. There may even be a role of MICA genes in the pathogenesis of BD. Various of these MHC class I molecules can be recognized by NK receptors on NK and NK-T-cells independently from peptides. These NK cell receptors may be activating (DS) or inhibitory (DL). Interestingly, increased percentages of CD4+CD16+ and CD4+CD56+ T-cell subsets have already been described in BD patients. …
Metadata
Title
Regulation of inflammatory CD28- T-helper cells by HLA class I molecules: a new cellular model for Behçet's disease?
Authors
C Duftner
C Goldberger
E Märker-Hermann
M Schirmer
Publication date
01-09-2003
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 2/2003
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar986

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