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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2003

01-06-2003 | Review

Behçet's disease

Authors: Shunsei Hirohata, Hirotoshi Kikuchi

Published in: Arthritis Research & Therapy | Issue 3/2003

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Abstract

Behçet's disease is characterized by recurrent aphthous stomatitis, uveitis, genital ulcers, and skin lesions. The role of the HLA-B*51 gene has been confirmed in recent years, although its contribution to the overall genetic susceptibility to Behçet's disease was estimated to be only 19%. The production of a variety of cytokines by T cells activated with multiple antigens has been shown to play a pivotal role in the activation of neutrophils. As regards the treatment, anti-tumor necrosis factor alpha therapy has been shown to be effective for mucocutaneous symptoms as well as for sight-threatening panuveitis, although a randomized, controlled trial is required.
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Metadata
Title
Behçet's disease
Authors
Shunsei Hirohata
Hirotoshi Kikuchi
Publication date
01-06-2003
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2003
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar757

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