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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2000

01-02-2000 | Review

Death, autoantigen modifications, and tolerance

Authors: Paul J Utz,, Timothy J Gensler, Paul Anderson

Published in: Arthritis Research & Therapy | Issue 2/2000

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Abstract

Autoantibodies present in the serum of patients with a variety of inflammatory diseases have proven useful as diagnostic markers and as probes with which to elucidate biochemical and signaling pathways. The mechanisms governing the generation of autoantibodies remain elusive, constituting a critical missing link in our understanding of rheumatologic illnesses. Several lines of experimentation in recent years have strongly implicated events surrounding cell death in this process. This review will address the potential role played by death-specific modifications of autoantigens in bypassing tolerance to highly conserved autoantigens, including nucleic acids, lipids, and proteins.
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Metadata
Title
Death, autoantigen modifications, and tolerance
Authors
Paul J Utz,
Timothy J Gensler
Paul Anderson
Publication date
01-02-2000
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2000
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar75

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16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

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