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Published in: Arthritis Research & Therapy 1/2002

01-02-2002 | Review

Adult mesenchymal stem cells and cell-based tissue engineering

Authors: Rocky S Tuan, Genevieve Boland, Richard Tuli

Published in: Arthritis Research & Therapy | Issue 1/2002

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Abstract

The identification of multipotential mesenchymal stem cells (MSCs) derived from adult human tissues, including bone marrow stroma and a number of connective tissues, has provided exciting prospects for cell-based tissue engineering and regeneration. This review focuses on the biology of MSCs, including their differentiation potentials in vitro and in vivo, and the application of MSCs in tissue engineering. Our current understanding of MSCs lags behind that of other stem cell types, such as hematopoietic stem cells. Future research should aim to define the cellular and molecular fingerprints of MSCs and elucidate their endogenous role(s) in normal and abnormal tissue functions.
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Metadata
Title
Adult mesenchymal stem cells and cell-based tissue engineering
Authors
Rocky S Tuan
Genevieve Boland
Richard Tuli
Publication date
01-02-2002
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2002
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar614

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