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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2002

01-02-2002 | Review

Drugs in development: bisphosphonates and metalloproteinase inhibitors

Authors: Jon B Catterall, Tim E Cawston

Published in: Arthritis Research & Therapy | Issue 1/2002

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Abstract

The destruction of bone and cartilage is characteristic of the progression of musculoskeletal diseases. The present review discusses the developments made with two different classes of drugs, the bisphosphonates and matrix metalloproteinase inhibitors. Bisphosphonates have proven to be an effective and safe treatment for the prevention of bone loss, especially in osteoporotic disease, and may have a role in the treatment of arthritic diseases. The development of matrix metalloproteinase inhibitors and their role as potential therapies are also discussed, especially in the light of the disappointing human trials data so far published.
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Metadata
Title
Drugs in development: bisphosphonates and metalloproteinase inhibitors
Authors
Jon B Catterall
Tim E Cawston
Publication date
01-02-2002
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 1/2002
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar604

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