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Published in: Arthritis Research & Therapy 3/2002

01-07-2002 | Review

Tissue engineering: chondrocytes and cartilage

Authors: Tim Hardingham, Simon Tew, Alan Murdoch

Published in: Arthritis Research & Therapy | Special Issue 3/2002

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Chapter summary

Tissue engineering offers new strategies for developing treatments for the repair and regeneration of damaged and diseased tissues. These treatments, using living cells, will exploit new developments in understanding the principles in cell biology that control and direct cell function. Arthritic diseases that affect so many people and have a major impact on the quality of life provide an important target for tissue engineering. Initial approaches are in cartilage repair; in our own programme we are elucidating the signals required by chondrocytes to promote new matrix assembly. These principles will extend to other tissues of the musculoskeletal system, including the repair of bone, ligament and tendon.
Literature
3.
go back to reference Venn G, Billingham MEJ, Hardingham TE: The increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. Arthritis Rheum. 1995, 38: 525-531.PubMedCrossRef Venn G, Billingham MEJ, Hardingham TE: The increased proteoglycan synthesis in cartilage in experimental canine osteoarthritis does not reflect a permanent change in chondrocyte phenotype. Arthritis Rheum. 1995, 38: 525-531.PubMedCrossRef
4.
go back to reference Hazell PK, Dent C, Fairclough JA, Bayliss MT, Hardingham TE: Changes in glycosaminoglycan epitope levels in knee joint fluid following injury. Arthritis Rheum. 1995, 38: 953-959.PubMedCrossRef Hazell PK, Dent C, Fairclough JA, Bayliss MT, Hardingham TE: Changes in glycosaminoglycan epitope levels in knee joint fluid following injury. Arthritis Rheum. 1995, 38: 953-959.PubMedCrossRef
5.
go back to reference Hardingham TE: Articular cartilage. In Oxford Textbook of Rheumatology. Edited by: Maddison PJ, Isenberg DA, Woo P, Glass DN. 1998, Oxford, New York, Tokyo: Oxford Medical Publications, 405-420. Hardingham TE: Articular cartilage. In Oxford Textbook of Rheumatology. Edited by: Maddison PJ, Isenberg DA, Woo P, Glass DN. 1998, Oxford, New York, Tokyo: Oxford Medical Publications, 405-420.
6.
go back to reference Goodstone NJ, Hardingham TE: Tumour necrosis factor alpha is a more potent inducer of nitric oxide synthase than inter-leukin-1 beta in porcine articular chondrocytes. Rheumatology. Goodstone NJ, Hardingham TE: Tumour necrosis factor alpha is a more potent inducer of nitric oxide synthase than inter-leukin-1 beta in porcine articular chondrocytes. Rheumatology.
7.
go back to reference Hardingham TE, Fosang AJ: The structure of aggrecan and its turnover in cartilage. J Rheumatol. 1995, 22 (Suppl 43): 86-90. Hardingham TE, Fosang AJ: The structure of aggrecan and its turnover in cartilage. J Rheumatol. 1995, 22 (Suppl 43): 86-90.
8.
go back to reference Fosang AJ, Hardingham TE: Matrix proteoglycans. In Extracellular Matrix. Edited by: Comper WD. 1996, The Netherlands: Harwood Academic Publishers, 2: 200-229. Fosang AJ, Hardingham TE: Matrix proteoglycans. In Extracellular Matrix. Edited by: Comper WD. 1996, The Netherlands: Harwood Academic Publishers, 2: 200-229.
9.
10.
go back to reference Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994, 331: 879-895. 10.1056/NEJM199410063311401.CrossRef Brittberg M, Lindahl A, Nilsson A, Ohlsson C, Isaksson O, Peterson L: Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation. N Engl J Med. 1994, 331: 879-895. 10.1056/NEJM199410063311401.CrossRef
11.
go back to reference Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 1999, 284: 143-147. 10.1016/S0304-3940(00)00981-2.PubMedCrossRef Pittenger MF, Mackay AM, Beck SC, Jaiswal RK, Douglas R, Mosca JD, Moorman MA, Simonetti DW, Craig S, Marshak DR: Multilineage potential of adult human mesenchymal stem cells. Science. 1999, 284: 143-147. 10.1016/S0304-3940(00)00981-2.PubMedCrossRef
12.
go back to reference Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Embryonic stem cell lines derived from human blastocysts. Science. 1998, 282: 1145-1147. 10.1006/bbrc.2001.4694.PubMedCrossRef Thomson JA, Itskovitz-Eldor J, Shapiro SS, Waknitz MA, Swiergiel JJ, Marshall VS, Jones JM: Embryonic stem cell lines derived from human blastocysts. Science. 1998, 282: 1145-1147. 10.1006/bbrc.2001.4694.PubMedCrossRef
13.
go back to reference Kolettas E, Muir HI, Barrett JC, Hardingham TE: Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. Rheumatology. 2001, 40: 1146-1156. 10.1093/rheumatology/40.10.1146.PubMedCrossRef Kolettas E, Muir HI, Barrett JC, Hardingham TE: Chondrocyte phenotype and cell survival are regulated by culture conditions and by specific cytokines through the expression of Sox-9 transcription factor. Rheumatology. 2001, 40: 1146-1156. 10.1093/rheumatology/40.10.1146.PubMedCrossRef
14.
go back to reference Lefebvre V, Li P, de Crombrugghe B: A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998, 17: 2336-2346. 10.1093/emboj/17.19.5718.CrossRef Lefebvre V, Li P, de Crombrugghe B: A new long form of Sox5 (L-Sox5), Sox6 and Sox9 are coexpressed in chondrogenesis and cooperatively activate the type II collagen gene. EMBO J. 1998, 17: 2336-2346. 10.1093/emboj/17.19.5718.CrossRef
15.
go back to reference Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K: Molecular cloning and expression of human UDP-D-xylose: proteoglycan core proteinβ-D-xylosyltransferase and its first isoform XT-II. J Mol Biol. 2000, 304: 517-528. 10.1006/jmbi.2000.4261.PubMedCrossRef Gotting C, Kuhn J, Zahn R, Brinkmann T, Kleesiek K: Molecular cloning and expression of human UDP-D-xylose: proteoglycan core proteinβ-D-xylosyltransferase and its first isoform XT-II. J Mol Biol. 2000, 304: 517-528. 10.1006/jmbi.2000.4261.PubMedCrossRef
16.
go back to reference Jakob M, Démarteau O, Schaefer D, Hintermann B, Dick W, Heberer M, Martin I: Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem. 2000, 81: 368-377. 10.1002/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J.CrossRef Jakob M, Démarteau O, Schaefer D, Hintermann B, Dick W, Heberer M, Martin I: Specific growth factors during the expansion and redifferentiation of adult human articular chondrocytes enhance chondrogenesis and cartilaginous tissue formation in vitro. J Cell Biochem. 2000, 81: 368-377. 10.1002/1097-4644(20010501)81:2<368::AID-JCB1051>3.0.CO;2-J.CrossRef
17.
go back to reference Gribbon P, Hardingham TE: Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching. Biophysical J. 1998, 75: 1032-1039.CrossRef Gribbon P, Hardingham TE: Macromolecular diffusion of biological polymers measured by confocal fluorescence recovery after photobleaching. Biophysical J. 1998, 75: 1032-1039.CrossRef
18.
go back to reference Gribbon P, Heng BC, Hardingham TE: The molecular basis of the solution properties of hyaluronan investigated by confocal-FRAP. Biophysical J. 1999, 77: 2210-2216.CrossRef Gribbon P, Heng BC, Hardingham TE: The molecular basis of the solution properties of hyaluronan investigated by confocal-FRAP. Biophysical J. 1999, 77: 2210-2216.CrossRef
19.
go back to reference Hardingham TE, Gribbon P: Confocal-FRAP analysis of ECM molecular interactions. In Extracellular Matrix Protocols. Edited by: Streuli C, Grant ME. 2000, Totowa, NJ: Humana Press, 83-93.CrossRef Hardingham TE, Gribbon P: Confocal-FRAP analysis of ECM molecular interactions. In Extracellular Matrix Protocols. Edited by: Streuli C, Grant ME. 2000, Totowa, NJ: Humana Press, 83-93.CrossRef
20.
go back to reference Gribbon P, Hardingham TE: Novel confocal-FRAP techniques for analysis of carbohydrate-protein interactions within the extracellular matrix. In Methods in Molecular Biology, Proteoglycan Protocols. Edited by: Lozzo RV. Totowa, NJ. 2001, Humana Press, 487-494.CrossRef Gribbon P, Hardingham TE: Novel confocal-FRAP techniques for analysis of carbohydrate-protein interactions within the extracellular matrix. In Methods in Molecular Biology, Proteoglycan Protocols. Edited by: Lozzo RV. Totowa, NJ. 2001, Humana Press, 487-494.CrossRef
21.
go back to reference Gribbon P, Heng BC, Hardingham TE: The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association. Biochem J. 2000, 350: 329-335. 10.1042/0264-6021:3500329.PubMedPubMedCentral Gribbon P, Heng BC, Hardingham TE: The analysis of intermolecular interactions in concentrated hyaluronan solutions suggest no evidence for chain-chain association. Biochem J. 2000, 350: 329-335. 10.1042/0264-6021:3500329.PubMedPubMedCentral
Metadata
Title
Tissue engineering: chondrocytes and cartilage
Authors
Tim Hardingham
Simon Tew
Alan Murdoch
Publication date
01-07-2002
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 3/2002
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar561

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