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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2002

01-08-2002 | Review

Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis

Authors: Ann-Sofie Hansson, Rikard Holmdahl

Published in: Arthritis Research & Therapy | Issue 5/2002

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Abstract

Relapsing polychondritis is an autoimmune disease in which an inappropriate immune response destroys cartilage. Cartilage of the ears, larynx and nose rather than spine and joint cartilage is affected by a chronic relapsing and erosive inflammation. Several animal models for relapsing polychondritis have been published in which immunization with various cartilage proteins induces a variety of chondritis symptoms that mimic those seen in patients. In this review we describe the collagens, matrilin-1 and cartilage oligomeric matrix protein as potential autoantigens able to trigger the tissue-specific immune response seen both in patients and in animal models for relapsing polychondritis and related autoimmune diseases.
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Metadata
Title
Cartilage-specific autoimmunity in animal models and clinical aspects in patients – focus on relapsing polychondritis
Authors
Ann-Sofie Hansson
Rikard Holmdahl
Publication date
01-08-2002
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2002
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar425

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