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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2013

01-06-2013 | Review

What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?

Authors: Joost F Swart, Sytze de Roock, Nico M Wulffraat

Published in: Arthritis Research & Therapy | Issue 3/2013

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Abstract

This review summarizes the immunological consequences of biological therapies used in juvenile idiopathic arthritis (JIA). For every frequently used biological agent the characteristics are clearly specified (molecular target, isotype, registered indication for JIA, route of administration, half-life, contraindication, very common side effects, expected time of response and average cost in the first year). The emphasis of this review is on the immunological side effects that have been encountered for every separate agent in JIA populations. For each agent these adverse events have been calculated as incidence per 100 patient-years for the following categories: serious infections, tuberculosis, malignancies, response to vaccination, new-onset autoimmune diseases and development of anti-drug antibodies. There are large differences in side effects between various agents and there is a clear need for an international and standardized collection of post-marketing surveillance data of biologicals in the vulnerable group of JIA patients. Such an international pharmacovigilance database, called Pharmachild, has now been started.
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Metadata
Title
What are the immunological consequences of long-term use of biological therapies for juvenile idiopathic arthritis?
Authors
Joost F Swart
Sytze de Roock
Nico M Wulffraat
Publication date
01-06-2013
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2013
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4213

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