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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 2/2013

01-04-2013 | Review

microRNA-mediated regulation of innate immune response in rheumatic diseases

Authors: Xiaobing Luo, Koustubh Ranade, Ronel Talker, Bahija Jallal, Nan Shen, Yihong Yao

Published in: Arthritis Research & Therapy | Issue 2/2013

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Abstract

miRNAs have been shown to play essential regulatory roles in the innate immune system. They function at multiple levels to shape the innate immune response and maintain homeostasis by direct suppression of the expression of their target proteins, preferentially crucial signaling components and transcription factors. Studies in humans and in disease models have revealed that dysregulation of several miRNAs such as miR-146a and miR-155 in rheumatic diseases leads to aberrant production of and/or signaling by inflammatory cytokines and, thus, critically contributes to disease pathogenesis. In addition, the recent description of the role of certain extracellular miRNAs as innate immune agonist to induce inflammatory response would have direct relevance to rheumatic diseases.
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Metadata
Title
microRNA-mediated regulation of innate immune response in rheumatic diseases
Authors
Xiaobing Luo
Koustubh Ranade
Ronel Talker
Bahija Jallal
Nan Shen
Yihong Yao
Publication date
01-04-2013
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 2/2013
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar4194

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