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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2012

01-06-2012 | Editorial

Statins: a revised appraisal for potential additional future treatment indications

Author: Robert Weissert

Published in: Arthritis Research & Therapy | Issue 3/2012

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Abstract

Beside statins' well established positive influence on atherosclerotic vascular disease caused by hypercholesterolemia through selective competitive inhibition of 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, additional effects on the immune system have been described for them. These observations have raised great hopes for additional future treatment indications, including rheumatoid arthritis and multiple sclerosis. Ten years of searching for such novel treatment indications have not led to breakthroughs and future efforts must be seen with skepticism.
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de Jong HJ, Klungel OH, van Dijk L, Vandebriel RJ, Leufkens HG, van der Laan J, Tervaert JW, van Loveren H: Use of statins is associated with an increased risk of rheumatoid arthritis. Ann Rheum Dis. 2012, 71: 648-654. 10.1136/ard.2011.155622.CrossRefPubMed
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Metadata
Title
Statins: a revised appraisal for potential additional future treatment indications
Author
Robert Weissert
Publication date
01-06-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3880

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