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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Th17 is involved in the pathogenesis of Bechet's disease via CCL20-CCR6 axis

Authors: Hidekata Yasuoka, Zhu Chen, Tsutomu Takeuchi, Masataka Kuwana

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Behcet's disease (BD) is an autoinflammatory disease with a unique distribution characterized by uveitis, and mucosal and skin lesions, which are characterized by the prominent infiltration of immune cells such as lymphocytes and neutrophils. A novel helper T-cell subset Th17, IL-17-producing helper T cells, has been appreciated [1]. IL-17 is involved in the induction of a series of chemokines, growth factors, proteases, and cytokines, and production of IL-17 results in induction of neutrophil migration and chronic inflammation [2]. Based on these findings, we hypothesized that Th17 is involved in the pathogenesis of BD. …
Literature
1.
Park H, Li Z, Yang XO, et al: A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol. 2005, 6: 1133-1141. 10.1038/ni1261.PubMedCentralCrossRefPubMed
2.
Metadata
Title
Th17 is involved in the pathogenesis of Bechet's disease via CCL20-CCR6 axis
Authors
Hidekata Yasuoka
Zhu Chen
Tsutomu Takeuchi
Masataka Kuwana
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3680

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