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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation

Authors: Takahide Tohmonda, Kazuhiro Chiba, Yoshiaki Toyama, Keisuke Horiuchi

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

To maintain the bone strength and functions, the balance between bone resorption and bone formation has to be tightly regulated. However, under certain pathological conditions, including osteoporosis and rheumatoid arthritis, the equilibrium gets disrupted, resulting in a severe bone loss. Recent studies have shown that signaling molecules involved in the unfolded protein response (UPR) are potentially involved in the coupling of bone resorption and bone formation [1‐3]. In the present study, we investigated the roles of UPR mediator, the IRE1α-XBP1 pathway in osteoblast differentiation. …
Literature
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Takayanagi H, Kim S, Matsuo K, Suzuki H, Suzuki T, Sato K, Yokochi T, Oda H, Nakamura K, Ida N, Wagner EF, Taniguchi T: RANKL maintains bone homeostasis through c-Fos-dependent induction of interferon-beta. Nature. 2002, 416: 744-9. 10.1038/416744a.CrossRefPubMed
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Smith JA, Turner MJ, DeLay ML, Klenk EI, Sowders DP, Colbert RA: Endoplasmic reticulum stress and the unfolded protein response are linked to synergistic IFN-beta induction via X-box binding protein 1. Eur J Immunol. 2008, 38: 1194-203. 10.1002/eji.200737882.PubMedCentralCrossRefPubMed
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Murakami T, Saito A, Hino S, Kondo S, Kanemoto S, Chihara K, Sekiya H, Tsumagari K, Ochiai K, Yoshinaga K, Saitoh M, Nishimura R, Yoneda T, Kou I, Furuichi T, Ikegawa S, Ikawa M, Okabe M, Wanaka A, Imaizumi K: Signalling mediated by the endoplasmic reticulum stress transducer OASIS is involved in bone formation. Nat Cell Biol. 2009, 11: 1205-11. 10.1038/ncb1963.CrossRefPubMed
Metadata
Title
Unfolded protein response mediator, the IRE1α-XBP1 pathway is involved in osteoblast differentiation
Authors
Takahide Tohmonda
Kazuhiro Chiba
Yoshiaki Toyama
Keisuke Horiuchi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3671

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