Published in:
Open Access
01-12-2012 | Poster presentation
Inhibition of Syndecan-4 by therapeutic antibodies reduces TNFα dependent joint destruction in mice
Authors:
Athanasios Stratis, Katja Neugebauer, Mareike Frohling, Peter Paruzel, Berno Dankbar, Corinna Wemeyer, Christoph Cromme, Lars Godmann, Jessica Bertrand, Adelheide Korb, Frank Echtermeyer, George Kollias, Thomas Pap
Published in:
Arthritis Research & Therapy
|
Special Issue 1/2012
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Excerpt
Syndecan-4, a member of a syndecan family of transmembrane heparansulfate proteoglycans has been recently associated with cell-matrix-adhesion, cell-migration, differentiation and proliferation, but its specific function in inflammatory pathologies remains unclear. We used the human TNFalpha transgenic mouse (hTNFtg) to analyse the expression and function of syndecan-4 in chronic-destructive-arthritis and answer the question whether inhibition of syndecan-4 by specific antibodies may prevent cartilagedestruction and/or improve the phenotype after onset of the disease in this animal model of human RA. …
