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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Smoking induces expression of ligands of the immune receptor NKG2D

Authors: Caroline Ospelt, Giovanni G Camici, Fabia Brentano, Peter Künzler, Christoph Kolling, Renate E Gay, Beat A Michel, Steffen Gay

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

While different studies confirmed an increased risk for smokers to develop rheumatoid arthritis (RA), the mechanisms behind this phenomenon are not known up to now. In all probability, smoking induces expression or post-translational modification of immune activating proteins which then initiate an autoimmune reaction in individuals with a susceptible genetic background. To identify these triggering molecules we screened joints of mice that were exposed to cigarette smoke for differences of gene expression and verified our results in synovial tissues of human smokers. …
Metadata
Title
Smoking induces expression of ligands of the immune receptor NKG2D
Authors
Caroline Ospelt
Giovanni G Camici
Fabia Brentano
Peter Künzler
Christoph Kolling
Renate E Gay
Beat A Michel
Steffen Gay
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3659

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