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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)

Authors: Tohru Nakanishi, Yuji Arai, Hiroki Mori, Toshihiro Nakajima, Toshikazu Kubo

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

CD81 belomgs to a family of cell-surface protein (tetraspanin) which has four transmembrane domains and two outer-membrane loops.Under the DNA chip analysis, we found several genes highly expressed in rheumatoid arthritis (RA) synoviocytes comparing with the expression in OA or normal synoviocytes. Among these genes, tetraspanin CD81 was shown to be involved in the progression of RA through the promotion of Synoviolin expression.Synoviolin is already known as one of the important progressive elements of RA in synoviocytes. We also showed Synoviolin and CD81 highly distributed in RA tissues. …
Literature
1.
Nakagawa Shuji, Arai Yuji, Mori Hiroki, Matsushita Yumi, Kubo Toshikazu, Nakanishi Tohru: Small interfering RNA targeting CD81 ameliorated arthritis in rats. Biochem Biophys Res Commun. 2009, 388: 467-472. 10.1016/j.bbrc.2009.06.150.CrossRefPubMed
Metadata
Title
Application of tetraspanin CD81 RNAi for diagnosis and therapy of rheumatoid arthritis (RA)
Authors
Tohru Nakanishi
Yuji Arai
Hiroki Mori
Toshihiro Nakajima
Toshikazu Kubo
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3653

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