Role of HLA-antigens class 1 in the development of rheumatoid arthritis in Uzbek women

Excerpt

According to the multiple studies women suffer from rheumatoid arthritis (RA) three times more often than men. The women seem to be ill at the age of more active working activity that results in early disability. The great attention is paid to the hereditary factors, particularly, to HLA-system, in the RA development. In this connection the question about early diagnosis and primary prevention of rheumatoid arthritis remain to be important. Consequently, we studied distribution of HLA I class antigens (A, B, C) in 86 Uzbek women with RA. HLA were identified with 2 step standard microlymphocytotoxicity test using antileucocyte HLA-antisera (St-Petersburg, Russia) and rabbit complement. Control group consist of 301 healthy random Uzbeks. In current study 39 antigens were expressed. Higher frequency was found for A25 (15.1% vs. 0.7% in control), A28 (22.1% vs. 4.9%, respectively) with p < 0.001. Antigen A19 (3.5% vs. 11.9% in control, p < 0.01). …