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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis

Authors: Silvia Hayer, B Niederreiter, J Smolen, K Redlich

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Previous studies demonstrated a regulatory role of interleukin 1 (IL-1) in inflammatory cartilage damage and bone destruction in human tumor necrosis factor transgenic (hTNFtg) mice, an animal model for Rheumatoid Arthritis (RA). Moreover, blocking of IL-6 has been shown to reduce local bone erosions in this model. Therefore we wanted to investigate the effect of a combined depletion of IL-1 and IL-6 on the development and severity of inflammatory, erosive arthritis. …
Metadata
Title
Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis
Authors
Silvia Hayer
B Niederreiter
J Smolen
K Redlich
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3645

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