Published in:
Open Access
01-12-2012 | Poster presentation
Effect of B cell depletion using peptide tetramers in collagen-induced arthritis
Authors:
Kazuya Michishita, Kimito Kawahata, Takeyuki Kanzaki, Lisa Akahira, Toshiki Eri, Kazuhiko Yamamoto
Published in:
Arthritis Research & Therapy
|
Special Issue 1/2012
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Excerpt
B cell depletion therapy is effective in the treatment of various autoimmune diseases. However, this therapy is shown to be associated with increased risk of adverse effects such as opportunistic infections. Therefore, in this study, we developed and analyzed the selective depletion therapy of pathogenic B cells using peptide tetramers in collagen-induced arthritis model. …