Skip to main content
Key Specialties
Cardiology Diabetology Endocrinology Gastroenterology Geriatrics and Gerontology Gynecology and Obstetrics Hematology Infectious Disease Internal Medicine Nephrology Neurology Oncology Pediatrics Respiratory Medicine Rheumatology Surgery
Congress Coverage
2024 ACC Congress 2023 ESMO Congress 2023 EASD Congress 2023 ERS Congress 2023 ESC Congress
Clinical Collections
Advances in Alzheimer’s

At a glance: The STEP trials

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.
ADVANCED SEARCH
Log in
Top
Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

Conditional inactivation of the ectodomain shedding of pro-TNFα in monocytes prevents lethality from LPS-induced septic shock

Authors: Keisuke Horiuchi, Tokuhiro Kimura, Yasunori Okada, Kazuhiro Chiba, Carl P Blobel, Yoshiaki Toyama

Published in: Arthritis Research & Therapy | Special Issue 1/2012

Login to get access

Excerpt

TNFα is synthesized as a membrane-bound precursor and proteolytically released from cells. Soluble TNFα is the primary mediator of pathologies such as rheumatoid arthritis, Crohn's disease, and endotoxin shock. Although several different enzymes have been implicated in this proteolytic activity, recent studies lean toward the TNFα converting enzyme (TACE/ADAM17) as the most relevant TNFαsheddase in vivo. In the present study, we asked whether the inactivation TACE could yield a protection from lipopolysaccharide(LPS)-induced septic shockin mice. …
Literature
1.
Horiuchi K, Kimura T, Miyamoto T, et al: TNF-α-converting enzyme (TACE/ADAM17) inactivation in mouse myeloid cells prevents lethality from endotoxin shock. J Immunol. 2007, 179: 2686-2689.CrossRefPubMed
Metadata
Title
Conditional inactivation of the ectodomain shedding of pro-TNFα in monocytes prevents lethality from LPS-induced septic shock
Authors
Keisuke Horiuchi
Tokuhiro Kimura
Yasunori Okada
Kazuhiro Chiba
Carl P Blobel
Yoshiaki Toyama
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3626

Other articles of this Special Issue 1/2012

Arthritis Research & Therapy 1/2012 Go to the issue

Poster presentation

Expression patterns and function of chromatin protein HMGB2 during mesenchymal stem cell differentiation

Oral presentation

Synovial fibroblasts display an uncontrolled inflammatory and tissue destructive response to TNF-α

Poster presentation

Neutrophils are the source of IL-17 and RANKL in zymosan induced arthritis

Oral presentation

Microparticles as antigenic targets in human and murine SLE

Poster presentation

Combined depletion of interleukin-1 and interleukin-6 does not exceed single depletion of interleukin -1 in TNF-mediated arthritis

Poster presentation

Intermittent cold stress-induced experimental fibromyalgia model in mice - pharmacology and neurobiology
Obesity Clinical Trial Summary

At a glance: The STEP trials

Read more

A round-up of the STEP phase 3 clinical trials evaluating semaglutide for weight loss in people with overweight or obesity.

Developed by: Springer Medicine

Highlights from the ACC 2024 Congress

Year in Review: Pediatric cardiology

Pediatric Cardiology Video

Watch Dr. Anne Marie Valente present the last year's highlights in pediatric and congenital heart disease in the official ACC.24 Year in Review session.

Year in Review: Pulmonary vascular disease

Cardiopulmonary Comorbidity Video

The last year's highlights in pulmonary vascular disease are presented by Dr. Jane Leopold in this official video from ACC.24.

Year in Review: Valvular heart disease

Valvular Heart Disease Video

Watch Prof. William Zoghbi present the last year's highlights in valvular heart disease from the official ACC.24 Year in Review session.

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

ACC 2024 Congress Coverage

Year in Review: Heart failure and cardiomyopathies

Heart Failure Video

Watch this official video from ACC.24. Dr. Biykem Bozkurt discusses last year's major advances in heart failure and cardiomyopathies.

Watch now

Semaglutide benefits people with type 2 diabetes and obesity-related heart failure

16-04-2024 Type 2 Diabetes News

Incentivised to exercise

11-04-2024 Lifestyle Modifications News

New intervention for STEMI-related cardiogenic shock

10-04-2024 Myocardial Infarction News

» View more highlights on the ACC 2024 congress hub page

Image Credits