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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP

Authors: Hidetoshi Fujita, Minako Nakazawa, Satoko Aratani, Kusuki Nishioka, Akiyoshi Fukamizu, Toshihiro Nakajima

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Rheumatoid arthritis (RA) is one of the most common articular diseases with a prevalence of 1% worldwide [1, 2]. The clinical features of RA include chronic inflammation of systemic joints associated with synovial hyperplasia followed by impairment of quality of life [3, 4]. Recently, we have shown that Synoviolin/Hrd1, an E3 ubiquitin ligase, is a novel causative factor for arthropathy [5]. However, the mechanism that regulates synovial cell outgrowth is not fully understood. …
Literature
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Harris ED: Rheumatoid arthritis. Pathophysiology and implications for therapy. N Engl J Med. 1990, 322: 1277-1289. 10.1056/NEJM199005033221805.CrossRefPubMed
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Feldmann M, Brennan FM, Maini RN: Rheumatoid arthritis. Cell. 1996, 85: 307-310. 10.1016/S0092-8674(00)81109-5.CrossRefPubMed
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Aarvak T, Natvig JB: Cell-cell interactions in synovitis: antigen presenting cells and T cell interaction in rheumatoid arthritis. Arthritis Res. 2001, 3: 13-17. 10.1186/ar135.PubMedCentralCrossRefPubMed
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Amano T, Yamasaki S, Yagishita N, Tsuchimochi K, Shin H, Kawahara K, Aratani S, Fujita H, Zhang L, Ikeda R, Fujii R, Miura N, Komiya S, Nishioka K, Maruyama I, Fukamizu A, Nakajima T: Synoviolin/Hrd1, an E3 ubiquitin ligase, as a novel pathogenic factor for arthropathy. Genes Dev. 2003, 17: 2436-2449. 10.1101/gad.1096603.PubMedCentralCrossRefPubMed
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Workman CJ, Wang Y, El Kasmi KC, Pardoll DM, Murray PJ, Drake CG, Vignali DA: LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol. 2009, 182: 1885-1891. 10.4049/jimmunol.0800185.PubMedCentralCrossRefPubMed
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Treibel F, Hacene K, Pichon MF: A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. Cancer Letters. 2006, 235: 147-153. 10.1016/j.canlet.2005.04.015.CrossRef
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Triebel F: LAG-3: a regulator of T-cell and DC responses and its use in therapeutic vaccination. Trends Immunol. 2003, 24: 619-622. 10.1016/j.it.2003.10.001.CrossRefPubMed
Metadata
Title
GCIP, Id like HLH protein, negatively regulates cell proliferation of rheumatoid synovial cells via interaction with CBP
Authors
Hidetoshi Fujita
Minako Nakazawa
Satoko Aratani
Kusuki Nishioka
Akiyoshi Fukamizu
Toshihiro Nakajima
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3618

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