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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

MiRs in RA: possible biomarkers and therapeutic targets

Authors: Maria Filkova, Caroline Ospelt, Joanna Stanczyk, Serena Vettori, Ladislav Senolt, Mojca Frank, Christoph Kolling, Beat A Michel, Renate E Gay, Steffen Gay, Astrid Jüngel

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

New concepts of therapy highlight an early use of effective treatment to prevent further joint damage in RA. Altered expression of epigenetic marks like miRs offers us the possibility to develop new diagnostic tools and novel therapeutic targets. …
Literature
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Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C, Gay R, Buckley CD, Tak PP, Gay S, Kyburz D: Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum. 2011, 63: 373-81. 10.1002/art.30115.PubMedCentralCrossRefPubMed
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Stanczyk J, Pedrioli DM, Brentano F, Sanchez-Pernaute O, Kolling C, Gay RE, Detmar M, Gay S, Kyburz D: Altered expression of MicroRNA in synovial fibroblasts and synovial tissue in rheumatoid arthritis. Arthritis Rheum. 2008, 58: 1001-9. 10.1002/art.23386.CrossRefPubMed
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Pauley KM, Satoh M, Chan AL, Bubb MR, Reeves WH, Chan EK: Upregulated miR-146a expression in peripheral blood mononuclear cells from rheumatoid arthritis patients. Arthritis Res Ther. 2008, 10: R101-10.1186/ar2344.PubMedCentralCrossRefPubMed
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Fulci V, Scappucci G, Sebastiani GD, Giannitti C, Franceschini D, Meloni F, Colombo T, Citarella F, Barnaba V, Minisola G, Galeazzi M, Macino G: miR-223 is overexpressed in T-lymphocytes of patients affected by rheumatoid arthritis. Hum Immunol. 2010, 71: 206-11. 10.1016/j.humimm.2009.11.008.CrossRefPubMed
Metadata
Title
MiRs in RA: possible biomarkers and therapeutic targets
Authors
Maria Filkova
Caroline Ospelt
Joanna Stanczyk
Serena Vettori
Ladislav Senolt
Mojca Frank
Christoph Kolling
Beat A Michel
Renate E Gay
Steffen Gay
Astrid Jüngel
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3615

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