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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Poster presentation

IL-17-producing ©™T cells are important for the development of arthritis in a rheumatoid arthritis model

Authors: Aoi Akitsu, Harumichi Ishigame, Shigeru Kakuta, Shinobu Saijo, Yoichiro Iwakura

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

IL-1 receptor antagonist deficient (Il1rn-/-) mice spontaneously develop arthritis. We previously demonstrated that IL-17 plays a crucial role in the development of arthritis in Il1rn-/- mice. Furthermore we showed that IL-1 Ra-deficiency in T cells is important for the development of arthritis. It is not known, however, which IL-17-producing cells are involved in the pathogenesis of arthritis in this model. …
Metadata
Title
IL-17-producing ©™T cells are important for the development of arthritis in a rheumatoid arthritis model
Authors
Aoi Akitsu
Harumichi Ishigame
Shigeru Kakuta
Shinobu Saijo
Yoichiro Iwakura
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3604

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