Published in:
Open Access
01-12-2012 | Oral presentation
Therapeutic targets for rheumatoid arthritis: lessons from animal models
Authors:
Yoichiro Iwakura, Shinobu Saijo, Susumu Nakae, Noriyuki Fujikado, Harumichi Ishigame, Masanori Murayama
Published in:
Arthritis Research & Therapy
|
Special Issue 1/2012
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Excerpt
We have generated two RA models, human T-cell leukemia virus type I (HTLV-I) transgenic mice and IL-1 receptor antagonist (Ra)-deficient (KO) mice, to elucidate the pathogenic mechanisms of the disease. Both models spontaneously developed arthritis closely resembling that of RA in humans. We found that TNF-, but not IL-6-, deficiency suppressed development of arthritis in IL-1Ra KO mice, while IL-6 but not TNF was involved in the HTLV-I transgenic mouse model [
1]. IL-17 was important in both models. These observations suggest that pathogenic roles of IL-6 and TNF are different and both TNF, IL-6, and IL-17 are good targets for therapeutics. …
