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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Oral presentation

Evidence for synovial fibroblasts spreading rheumatoid arthritis

Authors: Ulf Müller-Ladner, Stefanie Lefèvre, Birgit Zimmermann, Ingo H Tarner, Robert Dinser, Thomas Pap, Steffen Gay, Elena Neumann

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

Active rheumatoid arthritis (RA) is characterized by continuous progression of the inflammatory process, eventually affecting the majority of joints. Thus far, molecular and cellular pathways of disease progression are largely unknown. One of the key players in this destructive scenario are synovial fibroblasts (SF) which actively attach to, invade into and degrade articular cartilage. As RASF are able to migrate in vitro, the current series of experiments were designed to evaluate the potential of RASF to spread the disease in vivo in the SCID mouse model of RA. …
Metadata
Title
Evidence for synovial fibroblasts spreading rheumatoid arthritis
Authors
Ulf Müller-Ladner
Stefanie Lefèvre
Birgit Zimmermann
Ingo H Tarner
Robert Dinser
Thomas Pap
Steffen Gay
Elena Neumann
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3570

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