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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 1/2012

Open Access 01-12-2012 | Oral presentation

Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene

Authors: Yoshinaga Ito, Shimon Sakaguchi

Published in: Arthritis Research & Therapy | Special Issue 1/2012

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Excerpt

SKG mouse is a murine model of autoimmune arthritis. A spontaneous point mutation of the gene encoding an SH2 domain of the ζ-associated protein of 70 kDa gene (ZAP-70), a key signal transduction molecule in T cells, causes chronic autoimmune arthritis in SKG mice that resembles human RA in many aspects. Altered signal transduction from T-cell antigen receptor through the aberrant ZAP-70 changes the thresholds of T cells to thymic selection, leading to the positive selection of otherwise negatively selected autoimmune T cells. …
Metadata
Title
Autoimmune arthritis caused by altered thymic T-cell selection due to a mutation of the ZAP-70 gene
Authors
Yoshinaga Ito
Shimon Sakaguchi
Publication date
01-12-2012
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue Special Issue 1/2012
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3565

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