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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2011

01-08-2011 | Review

Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection

Author: Claudio Vitali

Published in: Arthritis Research & Therapy | Issue 4/2011

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Abstract

A clinical picture of dry eye and dry mouth with the histological counterpart of focal lymphocytic sialoadenitis, usually detected in minor salivary glands, is considered the hallmark of Sjögren's syndrome. The association of sicca complaints and focal sialoadenitis can be also found in a number of other diseases, including some systemic viral infections. Among these conditions, chronic hepatitis C virus infection, associated with mixed cryoglobulinaemia and extra-hepatic manifestations, and HIV infection, particularly in the phase of diffuse interstitial lymphocytic infiltration, may mimic the clinical and histological aspects of Sjögren's syndrome. However, each disorder is characterised by specific, disease-related immunopathological aspects. Besides sicca complaints, the various disorders may also share a number of systemic extra-glandular features and the possible development of mucosa-associated lymphoid tissue lymphomas. This latter event represents in all of these diseases the final result of an antigen-driven chronic stimulation of B lymphocytes.
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Metadata
Title
Immunopathologic differences of Sjögren's syndrome versus sicca syndrome in HCV and HIV infection
Author
Claudio Vitali
Publication date
01-08-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3361

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