Published in:
01-06-2011 | Editorial
IL-17 in spondyloarthritis: is the T-party over?
Authors:
Nataliya Yeremenko, Dominique Baeten
Published in:
Arthritis Research & Therapy
|
Issue 3/2011
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Abstract
The past decade has witnessed significant progress in revealing an important role for IL-17 in the pathogenesis of several immune-mediated inflammatory diseases. Recent studies have provided new insights into the cellular source of IL-17, originally identified as the signature cytokine of a distinct CD4+ T-cell subset known as Th17. Accumulating evidence suggests that the majority of the IL-17 released in inflammatory arthritis is produced by innate immune cells rather than T cells. Understanding molecular mechanisms behind these early innate immune responses will be the key to designing rational therapies targeting these important inflammatory pathways.