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Published in: Arthritis Research & Therapy 3/2011

01-06-2011 | Commentary

Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed

Authors: Christopher P Denton, Jerome Avouac, Frank Behrens, Daniel E Furst, Ivan Foeldvari, Marc Humbert, Doerte Huscher, Otylia Kowal-Bielecka, Marco Matucci-Cerinic, Peter Nash, Christian F Opitz, David Pittrow, Lewis J Rubin, James R Seibold, Oliver Distler

Published in: Arthritis Research & Therapy | Issue 3/2011

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Abstract

Pulmonary arterial hypertension (PAH) is a serious complication of systemic sclerosis (SSc). In clinical trials PAH-SSc has been grouped with other forms, including idiopathic PAH. The primary endpoint for most pivotal studies was improvement in exercise capacity. However, composite clinical endpoints that better reflect long-term outcome may be more meaningful. We discuss potential endpoints and consider why the same measures may not be appropriate for both idiopathic PAH and PAH-SSc due to inherent differences in clinical outcome and management strategies of these two forms of PAH. Failure to take this into account may compromise progress in managing PAH in SSc.
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Metadata
Title
Systemic sclerosis-associated pulmonary hypertension: why disease-specific composite endpoints are needed
Authors
Christopher P Denton
Jerome Avouac
Frank Behrens
Daniel E Furst
Ivan Foeldvari
Marc Humbert
Doerte Huscher
Otylia Kowal-Bielecka
Marco Matucci-Cerinic
Peter Nash
Christian F Opitz
David Pittrow
Lewis J Rubin
James R Seibold
Oliver Distler
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3346

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