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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2011

01-06-2011 | Review

Negative regulation of NF-κB and its involvement in rheumatoid arthritis

Authors: Geert van Loo, Rudi Beyaert

Published in: Arthritis Research & Therapy | Issue 3/2011

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Abstract

The transcription factor NF-κB plays crucial roles in the regulation of inflammation and mmune responses, and inappropriate NF-κB activity has been linked with many autoimmune and inflammatory diseases, including rheumatoid arthritis. Cells employ a multilayered control system to keep NF-κB signalling in check, including a repertoire of negative feedback regulators ensuring termination of NF-κB responses. Here we will review various negative regulatory mechanisms that have evolved to control NF-κB signalling and which have been implicated in the pathogenesis of rheumatoid arthritis.
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Metadata
Title
Negative regulation of NF-κB and its involvement in rheumatoid arthritis
Authors
Geert van Loo
Rudi Beyaert
Publication date
01-06-2011
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2011
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3324

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