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01-06-2011 | Review

Regulation of bone by the adaptive immune system in arthritis

Authors: Kazuo Okamoto, Hiroshi Takayanagi

Published in: Arthritis Research & Therapy | Issue 3/2011

Abstract

Studies on the immune regulation of osteoclasts in rheumatoid arthritis have promoted the new research field of 'osteoimmunology', which investigates the interplay between the skeletal and immune systems at the molecular level. Accumulating evidence lends support to the theory that bone destruction associated with rheumatoid arthritis is caused by the enhanced activity of osteoclasts, resulting from the activation of a unique helper T cell subset, 'Th17 cells'. Understanding the interaction between osteoclasts and the adaptive immune system in rheumatoid arthritis and the molecular mechanisms of Th17 development will lead to the development of potentially effective therapeutic strategies.

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Title: Regulation of bone by the adaptive immune system in arthritis
Authors: Kazuo Okamoto
Hiroshi Takayanagi
Publication date: 01-06-2011
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 3/2011
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar3323

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