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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 5/2010

Open Access 01-10-2010 | Research article

Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid

Authors: Edmund K Li, Tracy Y Zhu, Vivian Y Hung, Anthony W Kwok, Vivian W Lee, Kenneth K Lee, James F Griffith, Martin Li, Kong Chiu Wong, Ping Chung Leung, Ling Qin, Lai Shan Tam

Published in: Arthritis Research & Therapy | Issue 5/2010

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Abstract

Introduction

The purpose of this research is to assess the effects of oral ibandronate on bone microarchitecture by using high-resolution peripheral quantitative computed tomography (HR-pQCT) in patients with systemic lupus erythematosus (SLE) taking a long-term glucocorticoid.

Methods

In this double-blind placebo-controlled study, 40 Chinese female SLE patients taking prednisolone were randomly assigned to receive either monthly oral ibandronate (150 mg) or placebo with daily 1-hydroxycholecalciferol (Alfacalcidol; 1 μg) and calcium supplement for 12 months. Assessments of bone microarchitecture by using HR-pQCT and area bone mineral density (aBMD) of the lumbar spine and hip with dual-energy x-ray absorptiometry (DXA) were performed at baseline and 12 months.

Results

No differences in baseline characteristics were found between the two groups. After 12 months, no statistical differences were noted in any of the bone densities, microarchitectural parameters, or percentage changes of these parameters, as measured with HR-pQCT or DXA between the two groups. However, within the active group, the percentage improvement was significant in cortical bone density (P = 0.023) which was absent in the placebo group. Improvement was also seen in the aBMD of both the lumbar spine (P < 0.0001) and the hip (P < 0.005). In the placebo group, the percentage increase in trabecular separation was significant (P = 0.04), and the percentage improvement in aBMD in the spine also was significant (P = 0.049).

Conclusions

Oral ibandronate treatment improves microarchitecture in SLE patients taking long-term glucocorticoid assessed with HR-pQCT, and this new technology may have a role in assessing bony changes in future longitudinal studies in SLE patients.

Trial registration

ClinicalTrials.gov identifier: NCT00668330.
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Metadata
Title
Ibandronate increases cortical bone density in patients with systemic lupus erythematosus on long-term glucocorticoid
Authors
Edmund K Li
Tracy Y Zhu
Vivian Y Hung
Anthony W Kwok
Vivian W Lee
Kenneth K Lee
James F Griffith
Martin Li
Kong Chiu Wong
Ping Chung Leung
Ling Qin
Lai Shan Tam
Publication date
01-10-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 5/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3170

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