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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 4/2010

01-08-2010 | Letter

Bcl-xL affects the development of functional CD4 Tregs

Authors: Amir Sharabi, Edna Mozes

Published in: Arthritis Research & Therapy | Issue 4/2010

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Excerpt

We read with great interest the article by Haque and colleagues [1] in a recent issue of Arthritis Research & Therapy. They hypothesized that co-transduction of CD4+ T cells with both forkhead box P3 transcription factor (FoxP3) and Bcl-xL will generate highly reactive regulatory T cells (Tregs) that can be used to prevent auto immune disease. The authors showed that the accumulation, persistence, and efficient function of Tregs were attributable to the expression of Bcl-xL in CD4 Tregs. …
Literature
1.
Haque R, Lei F, Xiong X, Wu Y, Song J: FoxP3 and Bcl-xL cooperatively promote regulatory T cell persistence and prevention of arthritis development. Arthritis Res Ther. 2010, 12: R66-10.1186/ar2983.PubMedCentralCrossRefPubMed
2.
Sharabi A, Zinger H, Zborowsky M, Sthoeger ZM, Mozes E: A peptide based on the complementarity-determining region 1 of an autoantibody ameliorates lupus by up-regulating CD4+CD25+ cells and TGF-beta. Proc Natl Acad Sci USA. 2006, 103: 8810-8815. 10.1073/pnas.0603201103.PubMedCentralCrossRefPubMed
3.
Sharabi A, Luger D, Ben-David H, Dayan M, Zinger H, Mozes E: The role of apoptosis in the ameliorating effects of a CDR1-based peptide on lupus manifestations in a mouse model. J Immunol. 2007, 179: 4979-4987.CrossRefPubMed
4.
Sharabi A, Mozes E: The suppression of murine lupus by a tolerogenic peptide involves foxp3-expressing CD8 cells that are required for the optimal induction and function of foxp3-expressing CD4 cells. J Immunol. 2008, 181: 3243-3251.CrossRefPubMed
5.
Sharabi A, Lapter S, Mozes E: Bcl-xL is required for the development of functional regulatory CD4 cells in lupus-afflicted mice following treatment with a tolerogenic peptide. J Autoimmun. 2010, 34: 87-95. 10.1016/j.jaut.2009.06.002.CrossRefPubMed
Metadata
Title
Bcl-xL affects the development of functional CD4 Tregs
Authors
Amir Sharabi
Edna Mozes
Publication date
01-08-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 4/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3076

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