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Arthritis Research & Therapy
Published in: Arthritis Research & Therapy 3/2010

01-06-2010 | Editorial

The use of glucocorticoids in rheumatoid arthritis - no 'rational' approach yet

Authors: Sonali P Desai, Daniel H Solomon

Published in: Arthritis Research & Therapy | Issue 3/2010

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Abstract

The relationship between glucocorticoids and bone mineral density in rheumatoid arthritis is complex. Further study into the optimal dosing, timing and duration of glucocorticoid use in rheumatoid arthritis is necessary.
Appendix
Available only for authorised users
Literature
1.
Ibanez M, Ortiz AM, Castrejon I, Garcia-Vadillo A, Carvajal I, Castaneda S, Gonzalez-Alvaro I: A rational use of glucocorticoids in patients with early arthritis has a minimal impact on bone mass. Arthritis Res Ther. 12: R50-10.1186/ar2961.
2.
Gravallese EM, Harada Y, Wang JT, Gorn AH, Thornhill TS, Goldring SR: Identification of cell types responsible for bone resorption in rheumatoid arthritis and juvenile rheumatoid arthritis. Am J Pathol. 1998, 152: 943-951.PubMedCentralPubMed
3.
4.
Canalis E, Mazziotti G, Giustina A, Bilezikian JP: Glucocorticoid-induced osteoporosis: pathophysiology and therapy. Osteoporos Int. 2007, 18: 1319-1328. 10.1007/s00198-007-0394-0.CrossRefPubMed
5.
Maurice MM, Nakamura H, van der Voort EA, van Vliet AI, Staal FJ, Tak PP, Breedveld FC, Boers M, Verhoeven AC, Markusse HM, van de Laar MA, Westhovens R, van Denderen JC, van Zeben D, Dijkmans BA, Peeters AJ, Jacobs P, van den Brink HR, Schouten HJ, van der Heijde DM, Boonen A, van der Linden S: Randomised comparison of combined step-down prednisolone, methotrexate and sulphasalazine with sulphasalazine alone in early rheumatoid arthritis. Lancet. 1997, 350: 309-318. 10.1016/S0140-6736(97)01300-7.CrossRef
6.
Kirwan JR, Bijlsma JW, Boers M, Shea BJ: Effects of glucocorticoids on radiological progression in rheumatoid arthritis. Cochrane Database Syst Rev. 2007, CD006356-
7.
Ton FN, Gunawardene SC, Lee H, Neer RM: Effects of low-dose prednisone on bone metabolism. J Bone Miner Res. 2005, 20: 464-470. 10.1359/JBMR.041125.CrossRefPubMed
8.
Engvall IL, Svensson B, Tengstrand B, Brismar K, Hafstrom I: Impact of lowdose prednisolone on bone synthesis and resorption in early rheumatoid arthritis: experiences from a two-year randomized study. Arthritis Res Ther. 2008, 10: R128-10.1186/ar2542.PubMedCentralCrossRefPubMed
9.
Haugeberg G, Strand A, Kvien TK, Kirwan JR: Reduced loss of hand bone density with prednisolone in early rheumatoid arthritis: results from a randomized placebo-controlled trial. Arch Intern Med. 2005, 165: 1293-1297. 10.1001/archinte.165.11.1293.CrossRefPubMed
10.
Sliwinska-Stanczyk P, Pazdur J, Ziolkowska M, Jaworski J, Kaminska-Tchorzewska E, Lacki JK: The effect of methylprednisolone on proliferation of PBMCs obtained from steroid-sensitive and steroid-resistant rheumatoid arthritis patients. Scand J Rheumatol. 2007, 36: 167-171. 10.1080/03009740601154111.CrossRefPubMed
11.
Manenschijn L, van den Akker EL, Lamberts SW, van Rossum EF: Clinical features associated with glucocorticoid receptor polymorphisms. An overview. Ann N Y Acad Sci. 2009, 1179: 179-198. 10.1111/j.1749-6632.2009.05013.x.CrossRefPubMed
Metadata
Title
The use of glucocorticoids in rheumatoid arthritis - no 'rational' approach yet
Authors
Sonali P Desai
Daniel H Solomon
Publication date
01-06-2010
Publisher
BioMed Central
Published in
Arthritis Research & Therapy / Issue 3/2010
Electronic ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar3035

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