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Open Access 01-03-2001 | Research article

IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis

Authors: Martine Chabaud, Erik Lubberts, Leo Joosten, Wim van den Berg, Pierre Miossec

Published in: Arthritis Research & Therapy | Issue 3/2001

Abstract

The origin and role of IL-17, a T-cell derived cytokine, in cartilage and bone destruction during rheumatoid arthritis (RA) remain to be clarified. In human ex vivo models, addition of IL-17 enhanced IL-6 production and collagen destruction, and inhibited collagen synthesis by RA synovium explants. On mouse cartilage, IL-17 enhanced cartilage proteoglycan loss and inhibited its synthesis. On human RA bone explants, IL-17 also increased bone resorption and decreased formation. Addition of IL-1 in these conditions increased the effect of IL-17. Blocking of bone-derived endogenous IL-17 with specific inhibitors resulted in a protective inhibition of bone destruction. Conversely, intra-articular administration of IL-17 into a normal mouse joint induced cartilage degradation. In conclusion, the contribution of IL-17 derived from synovium and bone marrow T cells to joint destruction suggests the control of IL-17 for the treatment of RA.

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Title: IL-17 derived from juxta-articular bone and synovium contributes to joint degradation in rheumatoid arthritis
Authors: Martine Chabaud
Erik Lubberts
Leo Joosten
Wim van den Berg
Pierre Miossec
Publication date: 01-03-2001
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 3/2001
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar294

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