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01-12-2009 | Editorial

SAPHO syndrome: Is a range of pathogen-associated rheumatic diseases extended?

Author: Alexander P Rozin

Published in: Arthritis Research & Therapy | Issue 6/2009

Abstract

SAPHO syndrome, representing a constellation of synovitis, acne, palmo-plantar pustulosis, hyperostosis, and osteitis, is now recognized as a distinct medical entity: a reactive infectious osteitis. Genetic, immunological, and bacterial mechanisms are implicated in the development of the disease. Diagnostic problems may arise due to non-complete manifestations of SAPHO: either acne and arthritis or acne and anterior wall osteitis with an unclear pustulosis history. The interventional study of Assmann et al. is a significant addition to a long range of publications showing an association of SAPHO with Propionibacterium acnes. Randomized control studies are needed to confirm the effects of antibiotic therapy.

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Title: SAPHO syndrome: Is a range of pathogen-associated rheumatic diseases extended?
Author: Alexander P Rozin
Publication date: 01-12-2009
Publisher: BioMed Central
Published in: Arthritis Research & Therapy / Issue 6/2009
Electronic ISSN: 1478-6362
DOI: https://doi.org/10.1186/ar2837

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